Discover the Market’s Best MSM Supplement

Happy Body Organic Sulfur

(Pure 100% Additive-Free MSM)

Simply, The Most Optimal Form of MSM on The Market

Discover the Market’s Best MSM Supplement

Happy Body Organic Sulfur

(Pure 100% Additive-Free MSM Crystals)

The Most Optimal Form of MSM on The Market

Product Features:

• Premium, Pure MSM: Our MSM is simple, pure, high-dose & certified 100% additive-free.
• Pure MSM = Organic Sulfur: MSM is an organo-sulfur based mineral, and when MSM is certified pure it’s often referred to as “Organic Sulfur“.
• Crystals Vs. Capsules: MSM crystals are the only form of MSM that is 100% free from toxic additives & fillers, ensuring optimal absorption.
• 3rd Party Certified Quality: Each batch we create is independently certified to USP/ISO/cGMP standards.
• Tested For The Bad Stuff Too: All batches are tested for heavy metals, bacteria, molds, & VOC’s.
• Optimal Absorption: Our 100% additive-free MSM crystals provide unmatched absorption.
• High-Dose: Each teaspoon provides up to 10x the MSM per serving compared to standard MSM capsules.
• Easily The Best Value: Each 1 lb. bag provides 450,000 mg of MSM – 5x the quantity of most other MSM formats, at a fraction of the cost.
• 7 Out of 10 People Rate It 5 Stars: Today almost 72% of our 7,000+ 3rd party verified product reviews are for a full 5 stars
• Canada’s Most Trusted Brand: Happy Body is North America’s most trusted brand of premium MSM for 11 years straight.
• Size/Shelf Life: Sold in 1 lb. bags, with a 3 year shelf life.

From The Leading Brand of Pure MSM – Happy Body

• Certified Purity: Each batch of our MSM is independently verified to be pure & 100% free from toxic additives.
• Truly Risk-Free: 🙌 We witness the incredibly positive impacts that our pure MSM makes on our customers daily! We want you to experience it too, it’s why we’re confident enough to back every purchase with a full 90-day, full money-back guarantee. Simple…
• Best Quality / Best Value: From our premium MSM supplements to our speciality pain creams, with Happy Body you get the best quality at the best price.
• Fast, Free Shipping: Same business day shipping to your door fast & free.
• 5 Star Customer Support: Real humans, not bots. Fast, super-responsive customer service to answer & solve any product or order questions.
• 90 Day Full Satisfaction Guaranteed: Like we said, try it, if you don’t love it, we’ll refund you in full, easy…

 Buy Now 

Customer Reviews

All customer reviews are collected by SiteJabber, a Google approved, fully independent review collection service that verifies all reviews are from actual humans who have actually purchased & used our products.

Just remember, reviews are not a replacement for medical advice.

*Customer reviews are from verified customer purchases. Reviews and feedback are consumer’s personal experiences. These are for informational purposes and should not be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

 Learn More

What is MSM / Organic Sulfur?

• MSM is itself an organo-sulfur based mineral.
• Naturally occurring and found in all living cells.
• Often combined (needlessly) with other ingredients like glucosamine in low-impact joint supplements.
• MSM is very powerful as it’s made largely from high levels of Organic (bioactive) Sulfur.
• MSM is the optimal source for bioactive Sulfur – nothing comes close.

In fact, the vast majority of MSM’s benefits are derived from its ultra-high levels of organic (bioactive) Sulfur.

Organic Sulfur Vs. Standard MSM

The Optimal Choice For Your Money

• Certified Pure & Potent: Unlike MSM capsules, ours is pure. ZERO fillers, ZERO toxic additives, ZERO binders, just pure high-dose MSM.
• Unmatched Absorption: Having Zero additives = maximum bioavailability, providing superior benefits. Most other MSM formats can’t match our absorption due to added fillers & chemicals.
• MSM 💊 Don’t Come Close: Our Organic Sulfur crystals provide up to 10x the amount of MSM compared to standard MSM capsules on a per serving basis.
• The Best Value By Far: Also provides up to 5x more MSM per package versus buying MSM capsules, so why pay more for inferior quality?

Compare Different Formats of MSM

Based on Avg. Amounts of MSM Per Dose/Serving From Other Leading Brands.

Easily The Best Value

Why Is Organic Sulfur So Important?

Your body depends on Sulfur for a wide range of functions, yet so few understand it’s value or even that it’s the 3rd most required mineral (by volume) in the body after Calcium and Phosphorous.

This Is Some of What The Body Uses Bioactive Sulfur For:

Source: Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9(3), 290. doi: 10.3390/nu9030290. [PubMed]

Did You Also Know…

• You’re made of 2 things: Your body is primarily composed of two things: water 💧 +  minerals ⛰️.
• Number 3: After calcium & phosphorus, bioactive Sulfur is the most required mineral by the body (by volume).
• Low in vital minerals –> health & beauty suffer: Without enough essential minerals like Sulfur, both the body and appearance suffer, in a lot cases seriously.
• Mineral deficiency is rampant: Modern farming & food production practices have significantly reduced the mineral content in our diets.

Mineral Deficiency

A Key Driver of Illness

Mineral deficiency, specifically here, the lack of Sulfur, is a significant factor in many age-related health issues today.

Essential for health and appearance, Sulfur – and other vital minerals – have been significantly depleted from our soil due to modern farming practices.

Over the past 120 years, this slow degradation has left many people unknowingly deficient, and suffering needlessly.

This loss in mineral content is starkly illustrated by data on soil health below.

Mineral Content In Soil – Today Vs. 100 Years Ago

Sources: USDA data from 1963 and 1997, with projections based on Hamaker (1982). Additional sources: Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutrition & Metabolism. 2007;4:24. doi:10.1186/1743-7075-4-24. Townsend DM, Tew KD, Tapiero H: Sulfur containing amino acids and human disease. Biomed Pharmacother 2004, 58:47-55. doi:10.1016/j.biopha.2003.11.005

This chart illustrates findings from a landmark study on soil-mineral content from the early 1900s onward.

The research highlights how modern agricultural practices, such as chemical fertilizers and pesticides, have depleted essential minerals in the soil, leading to widespread deficiencies in crops and, consequently, in the human diet.

This is also not one-off research, there are significant number of studies that clearly show the sad nutritional state of our food chain.

A Simplified Illustration

Today, Many People Are Seriously Deficient

In fact, here’s what a researcher said after completing a large-scale study on sulfur deficiency:

“Sulfur deficiency is real. A large segment of the population is deficient in sulfur.”

Dr. Marcel E Nimni, MD.

Source: Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutrition & Metabolism. 2007;4:24. doi:10.1186/1743-7075-4-24.

Signs You May Be Lacking in Sulfur

The Big Drivers of Nutritional Deficiency

🧪 Pesticides and other “additives” inhibit plants from absorbing organic sulfur and other vital nutrients from our soil.

🚜 Years of intensive agriculture have depleted our soil’s natural sulfur reserves.

🏭 The final blow..? Industrial processing cooks and strips away what little nutrients survive the journey.

Source: Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutrition & Metabolism. 2007;4:24. doi:10.1186/1743-7075-4-24

  So…

If you’re suffering with pain, poor wellness, digestive challenges & appearance issues:

Don’t Overthink It…

1. Start simple.

2. Address common mineral deficiencies first.

You’ll be surprised how effective it can be.

3. Consider Organic Sulfur supplementation daily

Sulfur is one of the more common & damaging mineral deficiencies.

Based on the research, our reviews & track record, we think you’ll be VERY happy you did… 🙂

MSM Benefits

Learn more about the core benefits that pure MSM/Organic Sulfur can provide.

⚡

Aches & Discomfort

🟢 Reduces swelling while helping dampen pain impulses throughout the body.

🟢 Reduces muscle discomfort and speeds up muscle/joint recovery from work or exercise.

🟢 Combats joint aches & discomfort.

Sources: Smithson, K.A. Kellick, K. Mergenhagen, Chapter 16 – Nutritional Modulators of Pain in the Aging Population, E Modulators of Pain. Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

🔥

Inflammation

🟢 Supports the body’s response to inflammation at a cellular level.

🟢 Helps target & reduce cellular swelling across the body.

🟢 Helps modulate inflammatory responses.

🟢 Combats oxidative stress, a primary inflammation trigger.

🟢 Supports & promotes liver detoxification.

🟢 Boosts Glutathione production, which is the body’s master antioxidant.

Source(s): Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9(3), 290. doi: 10.3390/nu9030290. [PubMed] The Influence of Methylsulfonylmethane on Inflammation. US National Library of Medicine. National Institutes of Health. J Sports Med (Hindawi Publ Corp). 2016; 2016: 7498359. Mariè van der Merwe and Richard J. Bloomer. Toguchi, A., Noguchi, N., Kanno, T., Yamada, A. (2023). ] Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

🦵

Joint Health & Flexibility

🟢 Helps optimize production of synovial fluid, the body’s natural joint lubricant.

🟢 Helps manage inflammation around joint structures, easing aches, swelling & discomfort.

🟢 Rejuvenates & reinforces the connective tissues, giving joints better tensile strength & structure.

🟢 Helps improve flexibility & optimizes mobility, making joints less stiff.

Source(s): Usha, P. R., & Naidu, M. U. (2004). Randomized, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clinical Drug Investigation, 24(6), 353-363. Effects of Methylsulfonylmethane (MSM) on exercise-induced pain… International Society of Sports Nutrition, 14(1), 24. doi: 10.1186/s12970-017-0181-z. [PubMed]. Brien, S., Prescott, P., Bashir, N., Lewith, H., & Lewith, G. (2008). Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Osteoarthritis and Cartilage, 16(11), 1277-1288. doi: 10.1016/j.joca.2008.03.002. [PubMed]. Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

💇

Hair Thickness & Hair Health

🟢 Helps naturally thicken hair follicles while enhancing softness, volume, & sheen.

🟢 Boosts Keratin production, the foundational protein of your hair & nails.

🟢 Helps reduce inflammation under the skin & follicles, improving vital blood flow to hair follicles.

🟢 Creates optimal conditions for the body to create stronger, thicker, softer hair.

Source(s): Shanmugam, Srinivasan & Baskaran, Rengarajan. The Effect of Methylsulfonylmethane on Hair Growth and for the Treatment of Alopecia. Biomolecules & Therapeutics – BIOMOL THER. 17. 241-248. 10.4062/biomolther.2009.17.3.241. Miuzzuddin N et al. “Beneficial effects of a sulfur-containing supplement on hair and nail condition.” Natural Medicine Journal, vol. 11, no. 11 (2019). Anthonavage M, Benjamin RL, Withee E. “Effects of oral supplementation with methylsulfonylmethane on skin health and wrinkle reduction.” Natural Medicine Journal, vol. 7, no. 11 (2015). Shanmugam S, Baskaran R, Nagayya-Sriraman S, Yong CS, Choi HG, Woo JS, Yoo BK. “The effect of methylsulfonylmethane on hair growth promotion of magnesium ascorbyl phosphate for the treatment of alopecia.” Biomolecules & Therapeutics, 15(3), 153-158 (2007). Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

🌟

Skin / Complexion

🟢 Improves complexion by reducing inflammation in the derma.

🟢 Also improves complexion through detoxification of skin cells.

🟢 Drives deep moisturization of skin cells, reducing & helping repair rough, dry skin.

🟢 Tightens collagen junctions & increases collagen production naturally, targeting wrinkles, fine lines, & crow’s feet.

Source(s): Dermato-endocrinology, 4, 298–307. doi:10.4161/derm.22876. Guaitolini E1,2,3, Cavezzi A1,2,3, Cocchi S1,2,3, Colucci R1,2,3, Urso SU1,2,3, Quinzi V1,2,3. Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being. Methylsulfonylmethane (MSM) modulates oxidative stress-induced apoptosis and cytotoxicity in skin keratinocytes.” Journal of Dermatological Science. Authors: Kim, Park, Lee, Lee, and Hwang. Published: 2009. Anthonavage M, Benjamin RL, Withee E. “Effects of oral supplementation with methylsulfonylmethane on skin health and wrinkle reduction.” Natural Medicine Journal, vol. 7, no. 11 (2015). Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

🍏

Digestive Health

🟢 Helps combat inflammatory activity in the gut.

🟢 Boosts Collagen production, fortifying the digestive tract lining & reducing particles leaking from the gut (aka leaky gut).

🟢 Detoxifies & quickly increases cell permeability, facilitating waste expulsion.

🟢 Plays an important role in optimizing pH levels within the stomach.

🟢 Vital for certain beneficial gut bacteria, supporting an optimal gut microbiome.

🟢 Helps improve absorption of many nutrients & vitamins.

Source(s): Min Zhang, Ira G. Wong, Jerry B. Gin & Naseem H. Ansari (2009) Assessment of (MSM) methylsulfonylmethane as a permeability enhancer. 16:5, 243-248, DOI: 10.1080/10717540902896362. Ingenbleek Y., Kimura H. Nutritional essentiality of Sulfur in health and disease. Nutr. Rev. 2013;71:413–432. doi: 10.1111/nure.12050. Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9(3), 290. doi: 10.3390/nu9030290. [PubMed] Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

🛡️

Full Body Detoxification

With over 84,000 chemicals in everyday products, and only 15% of those actually tested for human safety, you really need to detoxify daily.

🟢 Helps sweep out toxins, heavy metals, and even lactic acids at the cellular level.

🟢 Able to cross the blood-brain barrier, helping support detoxification of brain cells.

🟢 Rapidly open cell membranes, optimizing & speeding toxin removal at a cellular level.

🟢 Binds to certain dangerous heavy metals, helping render them inert.

🟢 Optimizes the production of Glutathione, the body’s master antioxidant, & vital to liver detoxification.

Source(s): Fourth National Report on Human Exposure to Environmental Chemicals” – A report by the Centers for Disease Control and Prevention (CDC). (Source: CDC, 2019). Barrager E, Veltmann JR Jr, Schauss AG, Schiller RN. (2002) “A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis.” J Altern Complement Med Apr; 8(2): 167-73 Ingenbleek Y., Kimura H. Nutritional essentiality of Sulfur in health and disease. Nutr. Rev. 2013;71:413–432. doi: 10.1111/nure.12050. Sulfur amino acid deficiency depresses glutathione concentration. Paterson PG1, Lyon AW, Kamencic H, Andersen LB, Juurlink BH. Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

⚙️

Sulfur Is a Key For Building Block For Other Stuff

Sulfur is a key building block the body critically depends on.

🟢 Essential for over 140 vital body compounds. Many of these are mission-critical compounds that your body truly depends on for health, function, digestion & appearance.

🟢 Provides the body with vital disulfide bonds which are used to build: proteins, amino acids, enzymes, & antioxidants.

🟢 Examples of complex-compounds built with Sulfur:

• Glutathione
• Collagen
• Keratin
• Cystine
• Methionine
• Taurine
• Biotin

Source(s): Butawan, M., Benjamin, R. L., & Bloomer, R. J. (2017). Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients, 9(3), 290. http://doi.org/10.3390/nu903029. Nimni ME, Han B, Cordoba F. Are we getting enough sulfur in our diet? Nutrition & Metabolism. 2007;4:24. doi:10.1186/1743-7075-4-24. Townsend DM, Tew KD, Tapiero H: Sulfur containing amino acids and human disease. Biomed Pharmacother 2004, 58: 47-55. 10.1016/j.biopha.2003.11.005 Disclaimer: Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition. Informational purposes and should NOT ever be used as a replacement for medical advice or as a basis for self-diagnoses. Results will vary.

How To Use Organic Sulfur?

It’s Simple:

1. Just start with 1/4 to 1/2 a tsp. of the crystals in a small glass.

2. Add 1 – 2 oz. of filtered water or juice.

3. Swirl the glass & drink back.

You Can Grow Your Dose Over Time:

We suggest starting slow (1/4- 1/2 tsp. per dose),  as Sulfur is a very powerful detoxifying agent.

Then, over a few weeks of use, if you desire, you can begin to increase your dose, up to 1 tsp+, up to 2x a day, This is typically the optimal dose for most.

How Long To See Impacts?

Most people see impacts with consistent use after ⏰ 2 – 4 weeks.

Some see & feels impacts with in just days.

Timing will vary by person. You can see more FAQ’s further below.

It’s why we offer you a full 90 day money back guarantee.

*Customer impacts and timing vary. This is due to the complexities of peoples health history, other medications or supplements being taken at the same/similar times, consistency etc. Always discuss with your health professional before starting any new supplement.

 💡

Change Your Health & Beauty Simply, With Some Good-Old Common Sense, Quality Nutrition.

Try Pure Organic Sulfur, From The Leader In Pure, Specialty MSM

🟢 Pure, 100% additive-free MSM, independently certified to ISO / cGMP, & USP standards.

🟢 Ultra-high dose MSM, offering up to 10x more per serving than MSM pills/powders.

🟢 Best value per dose: costs up to 5x less than competitor versions.

🟢 5-star rated by over 72% of over 7,000+ reviews.

🟢 Backed by our complete, 90-day, full money-back guarantee.

🟢 The leading brand in North America for 11 years, serving over 200,000+ customers.

If You Want The Best Results… Just Use The Best!

Happy Body ™

 Buy Now 

Contact Us

For Orders & Questions: 9:00am – 4:30pm EST  | Mon – Fri |  (Toronto Time)

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References:

1. Debbi EM, et al Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study . BMC Complement Altern Med. (2011)
2.  El-Gindy A, et al Reflectance near-infrared spectroscopic method with Chemometric techniques for simultaneous determination of Chondroitin, glucosamine, and methyl sulfonyl methane . J AOAC Int. (2012)
3.  Williams KI, Burstein SH, Layne DS Dimethyl sulfone: isolation from cows’ milk . Proc Soc Exp Biol Med. (1966)
4.  Willemsen MA, et al Methylsulfonylmethane (MSM) ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid. Neuropediatrics. (2006)
5. Oshima Y., Amiel D., Theodosakis J. The effect of distilled methylsulfonylmethane (msm) on human chondrocytes in vitro. Osteoarthr. Cartil. 2007;15:C123. doi: 10.1016/S1063-4584(07)61846-9
6.  Joung YH, et al MSM enhances GH signaling via the Jak2/STAT5b pathway in osteoblast-like cells and osteoblast differentiation through the activation of STAT5b in MSCs . PLoS One. (2012)
7.  Nakhostin-Roohi B, et al Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men . J Pharm Pharmacol. (2011)
8. Grimble R.F. The effects of sulfur amino acid intake on immune function in humans. J. Nutr. 2006;136:1660S–1665S
9. Jacobs S, Appleton J. MSM: the definitive guide, vol. 25. Topanga: Freedom Press; 2004. doi:10.1016/S0197-4572(04)00065-5.
10.  Werchan PM, et al Right ventricular performance after monocrotaline-induced pulmonary hypertension . Am J Physiol. (1989)
11. Krieger DR, Schwartz HI, Feldman R, et al. Study report for: a pharmacokinetic dose-escalating evaluation of MSM in healthy male volunteers.; 2008.
12.  GC-MS identification of dimethyl sulfone in cow’s milk and other livestock products
13.  Cecil KM, et al Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation . J Comput Assist Tomogr. (2002)
14.  Parcell S Sulfur in human nutrition and applications in medicine . Altern Med Rev. (2002)
15. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methylsulfonylmethane supplements on acute and chronic rheumatoid arthritis rat model. Arafa NM1, Hamuda HM, Melek ST, Darwish SK.2013 Mar;29(2):187-201. doi: 10.1177/0748233711428643. Epub 2011 Dec 15.
16.  Rogovin JL Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy . Toxicol Lett. (2002)
17.  Apps P, Mmualefe L, McNutt JW Identification of volatiles from the secretions and excretions of African wild dogs (Lycaon pictus) . J Chem Ecol. (2012)
18.  Jin HF, et al Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats . Acta Pharmacol Sin. (2008)
19.  Barmaki S, et al Effect of methylsulfonylmethane supplementation on exercise – Induced muscle damage and total antioxidant capacity . J Sports Med Phys Fitness. (2012)
20. Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. J Pharm Pharmacol. 2011;63(10):1290–4. doi:10.1111/j.2042-7158.2011.01314.x.
21. Richmond VL Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins . Life Sci. (1986)
22. Gumina S, et al Arginine L-alpha-ketoglutarate, methylsulfonylmethane, hydrolyzed type I collagen and bromelain in rotator cuff tear repair: a prospective randomized study . Curr Med Res Opin. (2012)
23. Kalman DS, Feldman S, Scheinberg AR, Krieger DR, Bloomer RJ. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. J Int Soc Sports Nutr. 2012;9(1):46. doi:10.1186/1550-2783-9-46.
24. Anthonavage, Michael & Benjamin, Rodney. (2015). Effects of Oral Supplementation With Methylsulfonylmethane on Skin Health and Wrinkle Reduction. Natural Medicine Journal. Vol 7.
25. Song Y, et al Investigation of iminosulfuranes as novel transdermal penetration enhancers: enhancement activity and cytotoxicity . Pharm Res. (2005)
26.  Ben-Porath I, Weinberg RA The signals and pathways activating cellular senescence . Int J Biochem Cell Biol. (2005)
27.  Burger BV, et al Elemental sulfur identified in urine of cheetah, Acinonyx jubatus . J Chem Ecol. (2006)
28. A Randomized Double Blind Placebo Controlled Evaluation of MSM for Exercise Induced Discomfort/Pain. Douglas Kalman, Samantha Feldman, Adam Samson, and Diane Krieger Published Online:1 Apr 2013
29. Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial. Withee ED1, Tippens KM1, Dehen R1, Tibbitts D1, Hanes D1, Zwickey H1.
30. Mohammadi S, et al Protective effects of methylsulfonylmethane on hemodynamics and oxidative stress in monocrotaline-induced pulmonary hypertensive rats .Adv Pharmacol Sci. (2012)
31. Use of MSM in patients with knee osteoarthritis: Results of a randomized open-label comparative study of the efficacy and tolerability. Alekseeva LI1, Sharapova EP1, Kashevarova NG1, Taskina EA1, Anikin SG1, Korotkova TA1, Pyanykh SE2.
32.  Amirshahrokhi K, Bohlooli S, Chinifroush MM The effect of methylsulfonylmethane on the experimental colitis in the rat . Toxicol Appl Pharmacol. (2011)
33. A Pagonis, Thomas & Givissis, Panagiotis & Kritis, Aristeidis & C Christodoulou, Anastasios. (2014). The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility. International Journal of Orthopaedics. 1. 1-6. 10.6051/j.issn.2311-5106.2014.01.7.
34. Clarke T.C., Black L.I., Stussman B.J., Barnes P.M., Nahin R.L. Trends in the use of complementary health approaches among adults: United states, 2002–2012. Natl. Health Stat. Rep. 2015;79:1–16.
35. Krieger D.R., Schwartz H.I., Feldman R., Pino I., Vanzant A., Kalman D.S., Feldman S., Acosta A., Pardo P., Pezzullo J.C. A Pharmacokinetic Dose-Escalating Evaluation of MSM in Healthy Male Volunteers. Miami Research Associates; Miami, FL, USA: 2009. pp. 1–83.
36. Endoh T., Habe H., Yoshida T., Nojiri H., Omori T. A cysb-regulated and sigma54-dependent regulator, sfnr, is essential for dimethyl sulfone metabolism of pseudomonas putida strain ds1. Microbiology. 2003;149:991–1000. doi: 10.1099/mic.0.26031-0
37. Feng L, et al Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide . J Clin Invest. (1995)
38. Suppressive effect of methylsulfonylmethane (MSM) on type II collagen-induced arthritis in DBA/1J mice Takashi Hasegawa, Sugi Ueno, Shoichiro Kumamoto, Yasunobu Yoshikai
39. Kim YH, et al The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages . Biol Pharm Bull. (2009)

Disclaimer: Information presented on this site is of a general nature used for educational and information purposes only.  Statements or opinions about products and health conditions have not been evaluated by the US Food and Drug Administration or Health Canada. Products and information stated herein are not intended to diagnose, treat, cure, or prevent any disease or condition.  If you have any concerns about your own health or are wanting to use a new mineral supplement, vitamin or herbal supplement, you should always consult with your physician or other healthcare professional first. Do not use information on this site or on our social media pages as a replacement for validated medical information / opinion, or as a basis for self-diagnosis. This is the same for your pet; always consult with your veterinarian before starting your pet on any new pet supplement or vitamin first.

Pricing: For our website and catalog, the Regular (Reg) Price is also referred to as the MSRP is the “Manufacturer’s Suggested Retail Price.” The MSRP is understood to mean the price at which a manufacturer will recommend a retailer or reseller to sell a product for in stores, on the internet, or in catalogs. For Happy Body  branded items, the MSRP is calculated based on a varying percentage above the product’s completed production price & associated administration, marketing & logistics. Prices can change at any time for any reason. Pricing & sales offers can change at any time without notice, and at our sole discretion.